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Once Phosphorylated, Pgc1 Translocates From The Cytosol To The Nucleus, The Place It Promotes The Transcription Of Genes Involved In Fatty Acid Transport, Fat Oxidation, And Oxidative Phosphorylation Pgc1 Might Be Phosphorylated Through Several Completely Different Pathways, Amongst Them Ampk, Calcium Calmodulin Dependent Protein Kinase, And P38 Mitogen Activated Protein Kinase Pathways Pgc1 May Also Be Activated By A Sirt1 Mediated Deacetylation Ampk Can Exert Its Action Both Through Phosphorylation Of Pgc1 Or In A Direct Method At The Same Time, Ampk Activation Also Inhibits Mtor Signalling However, It Seems Counterintuitive To Inhibit An Important Growth Mediated Pathway Ie, Mtor , Regulating Muscle Mass, So That Skeletal Muscular Tissues Can Develop.
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